Association of olfactory dysfunction with risk for future Parkinson's disease
Identifieur interne : 000E62 ( Main/Exploration ); précédent : 000E61; suivant : 000E63Association of olfactory dysfunction with risk for future Parkinson's disease
Auteurs : G. Webster Ross [États-Unis] ; Helen Petrovitch [États-Unis] ; Robert D. Abbott [États-Unis, Japon] ; Caroline M. Tanner [États-Unis] ; Jordan Popper [États-Unis] ; Kamal Masaki [États-Unis] ; Lenore Launer [États-Unis] ; Lon R. White [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2008-02.
Abstract
Objective: Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it is not known whether such dysfunction can predate the onset of clinical PD in a community‐based population. This study examines the association of olfactory dysfunction with future development of PD in Honolulu‐Asia Aging Study cohort members Methods: Olfaction was assessed from 1991 to 1996 in 2,267 men in the Honolulu‐Asia Aging Study aged 71 to 95 years who were free of clinical PD and dementia at the time of olfaction testing. Participants were followed for up to 8 years for incident PD Results: In the course of follow‐up, 35 men were diagnosed with PD (24.6/10,000 person‐years). The average age at the time of diagnosis was 82.9 ± 3.8 (range, 76–93) years, and the average time to a diagnosis was 4.0 ± 1.9 (range, 1–8) years. During the first 4 years of follow‐up, age‐adjusted incidence of PD declined from 54.5/10,000 person‐years in the lowest quartile of odor identification to 26.6, 8.2, and 8.4/10,000 person‐years in the second, third, and fourth quartiles, respectively (p < 0.001 for trend). After adjustment for age and other potential confounders, the odds ratios for PD in the lowest quartile was 5.2 (95% confidence interval, 1.5–25.6) compared with the top two quartiles. This relation was not evident beyond 4 years of follow‐up Interpretation: Impaired olfaction can predate clinical PD in men by at least 4 years and may be a useful screening tool to detect those at high risk for development of PD in later life. Ann Neurol 2007
Url:
DOI: 10.1002/ana.21291
Affiliations:
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Tanner</name></author><author><name sortKey="Popper, Jordan" sort="Popper, Jordan" uniqKey="Popper J" first="Jordan" last="Popper">Jordan Popper</name></author><author><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name></author><author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name></author><author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. 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Burns School of Medicine, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Kuakini Medical Center/Honolulu‐Asia Aging Study, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Kuakini Medical Center/Honolulu‐Asia Aging Study, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Health Sciences, Shiga University of Medical Science, Otsu</wicri:regionArea><wicri:noRegion>Otsu</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Japan Society for the Promotion of Science, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson's Institute, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Popper, Jordan" sort="Popper, Jordan" uniqKey="Popper J" first="Jordan" last="Popper">Jordan Popper</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Departments of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Departments of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Kuakini Medical Center/Honolulu‐Asia Aging Study, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute on Aging, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Departments of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Departments of Geriatrics, University of Hawaii John A. Burns School of Medicine, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Pacific Health Research Institute, Honolulu</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Kuakini Medical Center/Honolulu‐Asia Aging Study, Honolulu</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-02">2008-02</date><biblScope unit="volume">63</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="167">167</biblScope><biblScope unit="page" to="173">173</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">B969D6DD32709C733E10077CC83C5F0912228885</idno><idno type="DOI">10.1002/ana.21291</idno><idno type="ArticleID">ANA21291</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it is not known whether such dysfunction can predate the onset of clinical PD in a community‐based population. This study examines the association of olfactory dysfunction with future development of PD in Honolulu‐Asia Aging Study cohort members Methods: Olfaction was assessed from 1991 to 1996 in 2,267 men in the Honolulu‐Asia Aging Study aged 71 to 95 years who were free of clinical PD and dementia at the time of olfaction testing. Participants were followed for up to 8 years for incident PD Results: In the course of follow‐up, 35 men were diagnosed with PD (24.6/10,000 person‐years). The average age at the time of diagnosis was 82.9 ± 3.8 (range, 76–93) years, and the average time to a diagnosis was 4.0 ± 1.9 (range, 1–8) years. During the first 4 years of follow‐up, age‐adjusted incidence of PD declined from 54.5/10,000 person‐years in the lowest quartile of odor identification to 26.6, 8.2, and 8.4/10,000 person‐years in the second, third, and fourth quartiles, respectively (p < 0.001 for trend). After adjustment for age and other potential confounders, the odds ratios for PD in the lowest quartile was 5.2 (95% confidence interval, 1.5–25.6) compared with the top two quartiles. This relation was not evident beyond 4 years of follow‐up Interpretation: Impaired olfaction can predate clinical PD in men by at least 4 years and may be a useful screening tool to detect those at high risk for development of PD in later life. Ann Neurol 2007</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Californie</li><li>Hawaï</li><li>Maryland</li><li>Virginie</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="États-Unis"><region name="Hawaï"><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name></region><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Popper, Jordan" sort="Popper, Jordan" uniqKey="Popper J" first="Jordan" last="Popper">Jordan Popper</name><name sortKey="Popper, Jordan" sort="Popper, Jordan" uniqKey="Popper J" first="Jordan" last="Popper">Jordan Popper</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name></country><country name="Japon"><noRegion><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name></noRegion><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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